About MAM domain-containing glycosylphosphatidylinositol anchor protein 1
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (MDGA1) is a protein
from Homo sapiens identified by UniProt accession
Q8NFP4, 955 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | MAM domain-containing glycosylphosphatidylinositol anchor protein 1 |
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| UniProt accession | Q8NFP4 |
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| Gene | MDGA1 |
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| Organism | Homo sapiens |
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| Length | 955 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.48
- insomnia measurement · score 0.44
- mathematical ability · score 0.42
- age-related hearing impairment · score 0.33
- chronotype measurement · score 0.32
- smoking status measurement · score 0.32
- diet measurement · score 0.30
- daytime rest measurement · score 0.27
- arterial stiffness measurement · score 0.22
- late-onset Alzheimers disease · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NFP4-F1 | alphafold | PREDICTED | 84.58 | — |
Amino-acid sequence (955 residues)
MEVTCLLLLA LIPFHCRGQG VYAPAQAQIV HAGQACVVKE DNISERVYTI REGDTLMLQC LVTGHPRPQV RWTKTAGSAS DKFQETSVFN ETLRIERIAR TQGGRYYCKA ENGVGVPAIK SIRVDVQYLD EPMLTVHQTV SDVRGNFYQE KTVFLRCTVN SNPPARFIWK RGSDTLSHSQ DNGVDIYEPL YTQGETKVLK LKNLRPQDYA SYTCQVSVRN VCGIPDKAIT FRLTNTTAPP ALKLSVNETL VVNPGENVTV QCLLTGGDPL PQLQWSHGPG PLPLGALAQG GTLSIPSVQA RDSGYYNCTA TNNVGNPAKK TVNLLVRSMK NATFQITPDV IKESENIQLG QDLKLSCHVD AVPQEKVTYQ WFKNGKPARM SKRLLVTRND PELPAVTSSL ELIDLHFSDY GTYLCMASFP GAPVPDLSVE VNISSETVPP TISVPKGRAV VTVREGSPAE LQCEVRGKPR PPVLWSRVDK EAALLPSGLP LEETPDGKLR LERVSRDMSG TYRCQTARYN GFNVRPREAQ VQLNVQFPPE VEPSSQDVRQ ALGRPVLLRC SLLRGSPQRI ASAVWRFKGQ LLPPPPVVPA AAEAPDHAEL RLDAVTRDSS GSYECSVSND VGSAACLFQV SAKAYSPEFY FDTPNPTRSH KLSKNYSYVL QWTQREPDAV DPVLNYRLSI RQLNQHNAVV KAIPVRRVEK GQLLEYILTD LRVPHSYEVR LTPYTTFGAG DMASRIIHYT EPINSPNLSD NTCHFEDEKI CGYTQDLTDN FDWTRQNALT QNPKRSPNTG PPTDISGTPE GYYMFIETSR PRELGDRARL VSPLYNASAK FYCVSFFYHM YGKHIGSLNL LVRSRNKGAL DTHAWSLSGN KGNVWQQAHV PISPSGPFQI IFEGVRGPGY LGDIAIDDVT LKKGECPRKQ TDPNKVVVMP GSGAPCQSSP QLWGPMAIFL LALQR
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