BPI fold-containing family B member 6 (BPIFB6)

About BPI fold-containing family B member 6

BPI fold-containing family B member 6 (BPIFB6) is a protein from Homo sapiens identified by UniProt accession Q8NFQ5, 453 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	BPI fold-containing family B member 6
UniProt accession	Q8NFQ5
Gene	BPIFB6
Organism	Homo sapiens
Length	453 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

ovarian cancer · score 0.18
lung adenocarcinoma · score 0.18
glioblastoma multiforme · score 0.17
endometrial cancer · score 0.15
squamous cell lung carcinoma · score 0.14
blood protein measurement · score 0.13
hair colour measurement · score 0.12
head and neck squamous cell carcinoma · score 0.12
breast adenocarcinoma · score 0.10
behavior · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NFQ5-F1	alphafold	PREDICTED	87.99	—

Amino-acid sequence (453 residues)

MLRILCLALC SLLTGTRADP GALLRLGMDI MNQVQSAMDE SHILEKMAAE AGKKQPGMKP IKGITNLKVK DVQLPVITLN FVPGVGIFQC VSTGMTVTGK SFMGGNMEII VALNITATNR LLRDEETGLP VFKSEGCEVI LVNVKTNLPS NMLPKMVNKF LDSTLHKVLP GLMCPAIDAV LVYVNRKWTN LSDPMPVGQM GTVKYVLMSA PATTASYIQL DFSPVVQQQK GKTIKLADAG EALTFPEGYA KGSSQLLLPA TFLSAELALL QKSFHVNIQD TMIGELPPQT TKTLARFIPE VAVAYPKSKP LTTQIKIKKP PKVTMKTGKS LLHLHSTLEM FAARWRSKAP MSLFLLEVHF NLKVQYSVHE NQLQMATSLD RLLSLSRKSS SIGNFNEREL TGFITSYLEE AYIPVVNDVL QVGLPLPDFL AMNYNLAELD IVENALMLDL KLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards