Torsin-1A-interacting protein 2 (TOR1AIP2)

About Torsin-1A-interacting protein 2

Torsin-1A-interacting protein 2 (TOR1AIP2) is a protein from Homo sapiens identified by UniProt accession Q8NFQ8, 470 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	Torsin-1A-interacting protein 2
UniProt accession	Q8NFQ8
Gene	TOR1AIP2
Organism	Homo sapiens
Length	470 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

cystatin C measurement · score 0.19
Abnormality of refraction · score 0.08
mean corpuscular volume · score 0.05
mean reticulocyte volume · score 0.04
mean corpuscular hemoglobin · score 0.03
prostate carcinoma · score 0.03
mean corpuscular hemoglobin concentration · score 0.03
smoking behavior · score 0.02
smoking initiation · score 0.02
Hepatic steatosis · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NFQ8-F1	alphafold	PREDICTED	69.19	—

Amino-acid sequence (470 residues)

MADSGLREPQ EDSQKDLEND PSVNSQAQET TIIASNAEEA EILHSACGLS KDHQEVETEG PESADTGDKS ESPDEANVGK HPKDKTEDEN KQSFLDGGKG HHLPSENLGK EPLDPDPSHS PSDKVGRADA HLGSSSVALP KEASDGTGAS QEPPTTDSQE AQSPGHSSAG QEGEDTLRRR LLAPEAGSHP QQTQKLEEIK ENAQDTMRQI NKKGFWSYGP VILVVLVVAV VASSVNSYYS SPAQQVPKNP ALEAFLAQFS QLEDKFPGQS SFLWQRGRKF LQKHLNASNP TEPATIIFTA AREGRETLKC LSHHVADAYT SSQKVSPIQI DGAGRTWQDS DTVKLLVDLE LSYGFENGQK AAVVHHFESF PAGSTLIFYK YCDHENAAFK DVALVLTVLL EEETLEASVG PRETEEKVRD LLWAKFTNSD TPTSFNHMDS DKLSGLWSRI SHLVLPVQPV SSIEEQGCLF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards