Serine palmitoyltransferase small subunit B (SPTSSB)

About Serine palmitoyltransferase small subunit B

Serine palmitoyltransferase small subunit B (SPTSSB) is a protein from Homo sapiens identified by UniProt accession Q8NFR3, 76 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.

Target properties

Protein name	Serine palmitoyltransferase small subunit B
UniProt accession	Q8NFR3
Gene	SPTSSB
Organism	Homo sapiens
Length	76 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (82)

Diseases linked to this target (Open Targets).

systolic blood pressure · score 0.27
risk-taking behaviour · score 0.27
Parkinson disease · score 0.27
serum urea measurement · score 0.24
leucine measurement · score 0.23
amino acid measurement · score 0.23
chronotype measurement · score 0.17
risky sexual behaviour measurement · score 0.12
lean body mass · score 0.11
body mass index · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NFR3-F1	alphafold	PREDICTED	86.53	—

Amino-acid sequence (76 residues)

MDLRRVKEYF SWLYYQYQII SCCAVLEPWE RSMFNTILLT IIAMVVYTAY VFIPIHIRLA WEFFSKICGY HSTISN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards