Metalloreductase STEAP2 (STEAP2)

About Metalloreductase STEAP2

Metalloreductase STEAP2 (STEAP2) is a protein from Homo sapiens identified by UniProt accession Q8NFT2, 490 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.

Target properties

Protein name	Metalloreductase STEAP2
UniProt accession	Q8NFT2
Gene	STEAP2
Organism	Homo sapiens
Length	490 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (82)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.44
diastolic blood pressure · score 0.43
pulse pressure measurement · score 0.42
glucose measurement · score 0.40
HbA1c measurement · score 0.32
hemoglobin A1 measurement · score 0.30
arterial stiffness measurement · score 0.23
coffee consumption measurement · score 0.20
coffee consumption · score 0.19
type 1 diabetes mellitus · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NFT2-F1	alphafold	PREDICTED	88.66	—

Amino-acid sequence (490 residues)

MESISMMGSP KSLSETFLPN GINGIKDARK VTVGVIGSGD FAKSLTIRLI RCGYHVVIGS RNPKFASEFF PHVVDVTHHE DALTKTNIIF VAIHREHYTS LWDLRHLLVG KILIDVSNNM RINQYPESNA EYLASLFPDS LIVKGFNVVS AWALQLGPKD ASRQVYICSN NIQARQQVIE LARQLNFIPI DLGSLSSARE IENLPLRLFT LWRGPVVVAI SLATFFFLYS FVRDVIHPYA RNQQSDFYKI PIEIVNKTLP IVAITLLSLV YLAGLLAAAY QLYYGTKYRR FPPWLETWLQ CRKQLGLLSF FFAMVHVAYS LCLPMRRSER YLFLNMAYQQ VHANIENSWN EEEVWRIEMY ISFGIMSLGL LSLLAVTSIP SVSNALNWRE FSFIQSTLGY VALLISTFHV LIYGWKRAFE EEYYRFYTPP NFVLALVLPS IVILGKIILF LPCISRKLKR IKKGWEKSQF LEEGMGGTIP HVSPERVTVM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards