About Protein DBF4 homolog B
Protein DBF4 homolog B (DBF4B) is a protein
from Homo sapiens identified by UniProt accession
Q8NFT6, 615 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | Protein DBF4 homolog B |
|---|
| UniProt accession | Q8NFT6 |
|---|
| Gene | DBF4B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 615 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (18)
Diseases linked to this target (Open Targets).
- body height · score 0.17
- cognitive function measurement · score 0.12
- platelet component distribution width · score 0.10
- lean body mass · score 0.05
- platelet crit · score 0.05
- fat body mass · score 0.04
- gut microbiome measurement · score 0.03
- whole body water mass · score 0.03
- psychiatric disorder · score 0.03
- refractive error · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NFT6-F1 | alphafold | PREDICTED | 54.84 | — |
Amino-acid sequence (615 residues)
MSEPGKGDDC LELESSMAES RLRAPDLGVS RCLGKCQKNS PGARKHPFSG KSFYLDLPAG KNLQFLTGAI QQLGGVIEGF LSKEVSYIVS SRREVKAESS GKSHRGCPSP SPSEVRVETS AMVDPKGSHP RPSRKPVDSV PLSRGKELLQ KAIRNQGSIS GGGSGGSSSL LTNARSWGVR ILHVDEMMMH VQQLSLASLC VKKQQPKKPE GTCPAAESRT RKVARLKAPF LKIEDESRKF RPFHHQFKSF PEISFLGPKD ASPFEAPTTL GSMHHTRESK DGEPSPRSAA HTMPRRKKGY CECCQEAFEE LHVHLQSAQH RSFALEAHLY AEVDRIIAQL SHSFADIPFQ AGLPRWSGSP ASDCDPLCPE TLHPHQPSHP RAASPRIRKE DSCQASVTQG RAAGQQRWTE SLDGVMGPPA SHTCVSATTL LPALPKGSRE QGCLCPCPAS FTQSHLVTSL ALLPGEWSPA EDMPLHPSQE NSFAPADIPV KGPLLFPEAR PWLMSARCWV RPFPFVTWGC LIPHDTTPLH EEVSPCPCLR LGYLYLLLTQ SLWCRVRVPS LSTAGPIPRT SHPCTLAFPS YLNDHDLGHL CQAKPQGWNT PQPFLHCGFL AVDSG
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