About Delta and Notch-like epidermal growth factor-related receptor
Delta and Notch-like epidermal growth factor-related receptor (DNER) is a protein
from Homo sapiens identified by UniProt accession
Q8NFT8, 737 residues long.
MolForge cross-references it against 0 known binders and
416 disease associations.
Target properties
| Protein name | Delta and Notch-like epidermal growth factor-related receptor |
|---|
| UniProt accession | Q8NFT8 |
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| Gene | DNER |
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| Organism | Homo sapiens |
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| Length | 737 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (416)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.39
- bone density · score 0.39
- FEV/FVC ratio · score 0.31
- lymphocyte count · score 0.30
- blood protein measurement · score 0.27
- vital capacity · score 0.23
- head and neck squamous cell carcinoma · score 0.22
- ulcerative colitis · score 0.22
- pulmonary function measurement · score 0.21
- smoking behaviour measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NFT8-F1 | alphafold | PREDICTED | 70.53 | — |
Amino-acid sequence (737 residues)
MQPRRAQAPG AQLLPALALL LLLLGAGPRG SSLANPVPAA PLSAPGPCAA QPCRNGGVCT SRPEPDPQHP APAGEPGYSC TCPAGISGAN CQLVADPCAS NPCHHGNCSS SSSSSSDGYL CICNEGYEGP NCEQALPSLP ATGWTESMAP RQLQPVPATQ EPDKILPRSQ ATVTLPTWQP KTGQKVVEMK WDQVEVIPDI ACGNASSNSS AGGRLVSFEV PQNTSVKIRQ DATASLILLW KVTATGFQQC SLIDGRSVTP LQASGGLVLL EEMLALGNNH FIGFVNDSVT KSIVALRLTL VVKVSTCVPG ESHANDLECS GKGKCTTKPS EATFSCTCEE QYVGTFCEEY DACQRKPCQN NASCIDANEK QDGSNFTCVC LPGYTGELCQ SKIDYCILDP CRNGATCISS LSGFTCQCPE GYFGSACEEK VDPCASSPCQ NNGTCYVDGV HFTCNCSPGF TGPTCAQLID FCALSPCAHG TCRSVGTSYK CLCDPGYHGL YCEEEYNECL SAPCLNAATC RDLVNGYECV CLAEYKGTHC ELYKDPCANV SCLNGATCDS DGLNGTCICA PGFTGEECDI DINECDSNPC HHGGSCLDQP NGYNCHCPHG WVGANCEIHL QWKSGHMAES LTNMPRHSLY IIIGALCVAF ILMLIILIVG ICRISRIEYQ GSSRPAYEEF YNCRSIDSEF SNAIASIRHA RFGKKSRPAM YDVSPIAYED YSPDDKPLVT LIKTKDL
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