Bestrophin-4 (BEST4)

About Bestrophin-4

Bestrophin-4 (BEST4) is a protein from Homo sapiens identified by UniProt accession Q8NFU0, 473 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	Bestrophin-4
UniProt accession	Q8NFU0
Gene	BEST4
Organism	Homo sapiens
Length	473 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

apolipoprotein B measurement · score 0.13
head and neck squamous cell carcinoma · score 0.12
low density lipoprotein cholesterol measurement · score 0.07
colorectal cancer · score 0.05
platelet component distribution width · score 0.04
intraocular pressure measurement · score 0.04
colorectal adenocarcinoma · score 0.04
Barrett's esophagus · score 0.03
Red cell distribution width · score 0.03
ulcerative colitis · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NFU0-F1	alphafold	PREDICTED	82.37	—

Amino-acid sequence (473 residues)

MTVSYTLKVA EARFGGFSGL LLRWRGSIYK LLYKEFLLFG ALYAVLSITY RLLLTQEQRY VYAQVARYCN RSADLIPLSF VLGFYVTLVV NRWWSQYTSI PLPDQLMCVI SASVHGVDQR GRLLRRTLIR YANLASVLVL RSVSTRVLKR FPTMEHVVDA GFMSQEERKK FESLKSDFNK YWVPCVWFTN LAAQARRDGR IRDDIALCLL LEELNKYRAK CSMLFHYDWI SIPLVYTQVV TIAVYSFFAL SLVGRQFVEP EAGAAKPQKL LKPGQEPAPA LGDPDMYVPL TTLLQFFFYA GWLKVAEQII NPFGEDDDDF ETNQLIDRNL QVSLLSVDEM YQNLPPAEKD QYWDEDQPQP PYTVATAAES LRPSFLGSTF NLRMSDDPEQ SLQVEASPGS GRPAPAAQTP LLGRFLGVGA PSPAISLRNF GRVRGTPRPP HLLRFRAEEG GDPEAAARIE EESAESGDEA LEP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards