About Bestrophin-2a
Bestrophin-2a (BEST2) is a protein
from Homo sapiens identified by UniProt accession
Q8NFU1, 509 residues long.
MolForge cross-references it against 0 known binders and
73 disease associations.
Target properties
| Protein name | Bestrophin-2a |
|---|
| UniProt accession | Q8NFU1 |
|---|
| Gene | BEST2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 509 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (73)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.18
- neurodegenerative disease · score 0.16
- breast adenocarcinoma · score 0.16
- mean corpuscular volume · score 0.12
- head and neck squamous cell carcinoma · score 0.12
- X-linked endothelial corneal dystrophy · score 0.08
- autosomal dominant keratitis · score 0.08
- Fuchs endothelial corneal dystrophy · score 0.08
- X-linked corneal dermoid · score 0.07
- corneal dystrophy, punctiform and polychromatic pre-descemet · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NFU1-F1 | alphafold | PREDICTED | 80.32 | — |
Amino-acid sequence (509 residues)
MTVTYTARVA NARFGGFSQL LLLWRGSIYK LLWRELLCFL GFYMALSAAY RFVLTEGQKR YFEKLVIYCD QYASLIPVSF VLGFYVTLVV NRWWSQYLCM PLPDALMCVV AGTVHGRDDR GRLYRRTLMR YAGLSAVLIL RSVSTAVFKR FPTIDHVVEA GFMTREERKK FENLNSSYNK YWVPCVWFSN LAAQARREGR IRDNSALKLL LEELNVFRGK CGMLFHYDWI SVPLVYTQVV TIALYSYFLA CLIGRQFLDP AQGYKDHDLD LCVPIFTLLQ FFFYAGWLKV AEQLINPFGE DDDDFETNFL IDRNFQVSML AVDEMYDDLA VLEKDLYWDA AEARAPYTAA TVFQLRQPSF QGSTFDITLA KEDMQFQRLD GLDGPMGEAP GDFLQRLLPA GAGMVAGGPL GRRLSFLLRK NSCVSEASTG ASCSCAVVPE GAAPECSCGD PLLDPGLPEP EAPPPAGPEP LTLIPGPVEP FSIVTMPGPR GPAPPWLPSP IGEEEENLA
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