About Collagen alpha-1(XXII) chain
Collagen alpha-1(XXII) chain (COL22A1) is a protein
from Homo sapiens identified by UniProt accession
Q8NFW1, 1626 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Collagen alpha-1(XXII) chain |
|---|
| UniProt accession | Q8NFW1 |
|---|
| Gene | COL22A1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 1626 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (65)
Diseases linked to this target (Open Targets).
- retinal detachment · score 0.44
- cortical surface area measurement · score 0.39
- gut microbiome measurement · score 0.39
- retinal break · score 0.37
- brain measurement · score 0.32
- taxonomic microbiome measurement · score 0.27
- PHF-tau measurement · score 0.25
- breast adenocarcinoma · score 0.25
- sitting height measurement · score 0.17
- endometrial cancer · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NFW1-F1 | alphafold | PREDICTED | 52.57 | — |
Amino-acid sequence (1626 residues)
MAGLRGNAVA GLLWMLLLWS GGGGCQAQRA GCKSVHYDLV FLLDTSSSVG KEDFEKVRQW VANLVDTFEV GPDRTRVGVV RYSDRPTTAF ELGLFGSQEE VKAAARRLAY HGGNTNTGDA LRYITARSFS PHAGGRPRDR AYKQVAILLT DGRSQDLVLD AAAAAHRAGI RIFAVGVGEA LKEELEEIAS EPKSAHVFHV SDFNAIDKIR GKLRRRLCEN VLCPSVRVEG DRFKHTNGGT KEITGFDLMD LFSVKEILGK RENGAQSSYV RMGSFPVVQS TEDVFPQGLP DEYAFVTTFR FRKTSRKEDW YIWQVIDQYS IPQVSIRLDG ENKAVEYNAV GAMKDAVRVV FRGSRVNDLF DRDWHKMALS IQAQNVSLHI DCALVQTLPI EERENIDIQG KTVIGKRLYD SVPIDFDLQR IVIYCDSRHA ELETCCDIPS GPCQVTVVTE PPPPPPPQRP PTPGSEQIGF LKTINCSCPA GEKGEMGVAG PMGLPGPKGD IGAIGPVGAP GPKGEKGDVG IGPFGQGEKG EKGSLGLPGP PGRDGSKGMR GEPGELGEPG LPGEVGMRGP QGPPGLPGPP GRVGAPGLQG ERGEKGTRGE KGERGLDGFP GKPGDTGQQG RPGPSGVAGP QGEKGDVGPA GPPGVPGSVV QQEGLKGEQG APGPRGHQGA PGPPGARGPI GPEGRDGPPG LQGLRGKKGD MGPPGIPGLL GLQGPPGPPG VPGPPGPGGS PGLPGEIGFP GKPGPPGPTG PPGKDGPNGP PGPPGTKGEP GERGEDGLPG KPGLRGEIGE QGLAGRPGEK GEAGLPGAPG FPGVRGEKGD QGEKGELGLP GLKGDRGEKG EAGPAGPPGL PGTTSLFTPH PRMPGEQGPK GEKGDPGLPG EPGLQGRPGE LGPQGPTGPP GAKGQEGAHG APGAAGNPGA PGHVGAPGPS GPPGSVGAPG LRGTPGKDGE RGEKGAAGEE GSPGPVGPRG DPGAPGLPGP PGKGKDGEPG LRGSPGLPGP LGTKAACGKV RGSENCALGG QCVKGDRGAP GIPGSPGSRG DPGIGVAGPP GPSGPPGDKG SPGSRGLPGF PGPQGPAGRD GAPGNPGERG PPGKPGLSSL LSPGDINLLA KDVCNDCPPG PPGLPGLPGF KGDKGVPGKP GREGTEGKKG EAGPPGLPGP PGIAGPQGSQ GERGADGEVG QKGDQGHPGV PGFMGPPGNP GPPGADGIAG AAGPPGIQGS PGKEGPPGPQ GPSGLPGIPG EEGKEGRDGK PGPPGEPGKA GEPGLPGPEG ARGPPGFKGH TGDSGAPGPR GESGAMGLPG QEGLPGKDGD TGPTGPQGPQ GPRGPPGKNG SPGSPGEPGP SGTPGQKGSK GENGSPGLPG FLGPRGPPGE PGEKGVPGKE GVPGKPGEPG FKGERGDPGI KGDKGPPGGK GQPGDPGIPG HKGHTGLMGP QGLPGENGPV GPPGPPGQPG FPGLRGESPS METLRRLIQE ELGKQLETRL AYLLAQMPPA YMKSSQGRPG PPGPPGKDGL PGRAGPMGEP GRPGQGGLEG PSGPIGPKGE RGAKGDPGAP GVGLRGEMGP PGIPGQPGEP GYAKDGLPGI PGPQGETGPA GHPGLPGPPG PPGQCDPSQC AYFASLAARP GNVKGP
Explore Collagen alpha-1(XXII) chain with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets