Diencephalon/mesencephalon homeobox protein 1 (DMBX1)

About Diencephalon/mesencephalon homeobox protein 1

Diencephalon/mesencephalon homeobox protein 1 (DMBX1) is a protein from Homo sapiens identified by UniProt accession Q8NFW5, 382 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	Diencephalon/mesencephalon homeobox protein 1
UniProt accession	Q8NFW5
Gene	DMBX1
Organism	Homo sapiens
Length	382 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (49)

Diseases linked to this target (Open Targets).

Hypotonia · score 0.26
Global developmental delay · score 0.26
Hearing impairment · score 0.26
Seizure · score 0.26
Strabismus · score 0.26
Hypermetropia · score 0.26
neurodegenerative disease · score 0.25
lysosomal storage disease · score 0.21
Alzheimer disease · score 0.21
Parkinson disease · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NFW5-F1	alphafold	PREDICTED	62.07	—

Amino-acid sequence (382 residues)

MQHYGVNGYS LHAMNSLSAM YNLHQQAAQQ AQHAPDYRPS VHALTLAERL AGCTFQDIIL EARYGSQHRK QRRSRTAFTA QQLEALEKTF QKTHYPDVVM RERLAMCTNL PEARVQVWFK NRRAKFRKKQ RSLQKEQLQK QKEAEGSHGE GKAEAPTPDT QLDTEQPPRL PGSDPPAELH LSLSEQSASE SAPEDQPDRE EDPRAGAEDP KAEKSPGADS KGLGCKRGSP KADSPGSLTI TPVAPGGGLL GPSHSYSSSP LSLFRLQEQF RQHMAATNNL VHYSSFEVGG PAPAAAAAAA AVPYLGVNMA PLGSLHCQSY YQSLSAAAAA HQGVWGSPLL PAPPAGLAPA SATLNSKTTS IENLRLRAKQ HAASLGLDTL PN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards