N-acylneuraminate cytidylyltransferase (CMAS)

About N-acylneuraminate cytidylyltransferase

N-acylneuraminate cytidylyltransferase (CMAS) is a protein from Homo sapiens identified by UniProt accession Q8NFW8, 434 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	N-acylneuraminate cytidylyltransferase
UniProt accession	Q8NFW8
Gene	CMAS
Organism	Homo sapiens
Length	434 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.43
pancreatic adenocarcinoma · score 0.21
neuroinflammatory disorder · score 0.15
Benign familial chorea · score 0.05
triple-negative breast cancer · score 0.04
body height · score 0.03
cancer · score 0.03
neoplasm · score 0.02
breast cancer · score 0.01
infection · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NFW8-F1	alphafold	PREDICTED	87.73	—

Amino-acid sequence (434 residues)

MDSVEKGAAT SVSNPRGRPS RGRPPKLQRN SRGGQGRGVE KPPHLAALIL ARGGSKGIPL KNIKHLAGVP LIGWVLRAAL DSGAFQSVWV STDHDEIENV AKQFGAQVHR RSSEVSKDSS TSLDAIIEFL NYHNEVDIVG NIQATSPCLH PTDLQKVAEM IREEGYDSVF SVVRRHQFRW SEIQKGVREV TEPLNLNPAK RPRRQDWDGE LYENGSFYFA KRHLIEMGYL QGGKMAYYEM RAEHSVDIDV DIDWPIAEQR VLRYGYFGKE KLKEIKLLVC NIDGCLTNGH IYVSGDQKEI ISYDVKDAIG ISLLKKSGIE VRLISERACS KQTLSSLKLD CKMEVSVSDK LAVVDEWRKE MGLCWKEVAY LGNEVSDEEC LKRVGLSGAP ADACSTAQKA VGYICKCNGG RGAIREFAEH ICLLMEKVNN SCQK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards