About Rab effector MyRIP
Rab effector MyRIP (MYRIP) is a protein
from Homo sapiens identified by UniProt accession
Q8NFW9, 859 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Rab effector MyRIP |
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| UniProt accession | Q8NFW9 |
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| Gene | MYRIP |
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| Organism | Homo sapiens |
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| Length | 859 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (55)
Diseases linked to this target (Open Targets).
- arterial stiffness measurement · score 0.28
- DNA methylation · score 0.25
- endometrial cancer · score 0.18
- metabolite measurement · score 0.13
- eosinophil count · score 0.06
- drug use measurement · score 0.05
- chronic pancreatitis · score 0.05
- hyperinsulinemic hypoglycemia, familial, 2 · score 0.05
- hyperinsulinemic hypoglycemia, familial, 1 · score 0.04
- pancreatic agenesis 2 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NFW9-F1 | alphafold | PREDICTED | 57.69 | — |
Amino-acid sequence (859 residues)
MGRKLDLSGL TDDETEHVLQ VVQRDFNLRK KEEERLSELK QKLDEEGSKC SILSKHQQFV EHCCMRCCSP FTFLVNTKRQ CGDCKFNVCK SCCSYQKHEK AWVCCVCQQA RLLRAQSLEW FYNNVKSRFK RFGSAKVLKN LYRKHRLESG ACFDILGGSL FESNLENEGS ISGSDSTFYR QSEGHSVMDT LAVALRVAEE AIEEAISKAE AYGDSLDKQN EASYLRDHKE ELTEELATTI LQKIIRKQKS KSEQQVEEEP GWPHPQSCST KVADEGTSAS PGGYRAPAAL WRSQSAFSIT GEEALKTPPV EAPSRQPRDQ GQHPRAESAL PSWKSVDRLD ETNLAPVLQS PDGNWVALKD GAPPPTRLLA KPKSGTFQAL EVASSVASAY DEMGSDSEED FDWSEALSKL CPRSRALPRN PQPQPTQAQS SDQGPIAASP SSALSPNPEA MCSDSETSSA GSSREVGHQA RLSWLQRKAP RNPAAEKMRL HGELDVNFNP QLASRETSDS SEPEEAPHTT DRRARRWRRA RLGSEEPSKE PSSPSAQLRD LDTHQVSDDL SETDISNEAR DPQTLTDTTE EKRRNRLYEL AMKMSEKETS SGEDQESEPK TESENQKESL SSEDNSQSVQ EELKKKFSAV SLCNISTEVL KVINATEELI AGSTGPWESP QVPPDRQKGM FPRGTDQVRL DEQLTSLEEN VYLAAGTVYG LETQLTELED AARCIHSGTD ETHLADLEDQ VATAAAQVHH AELQISDIES RISALTIAGL NIAPCVRFTR RRDQKQRTQV QTIDTSRQQR RKLPAPPVKA EKIETSSVTT IKTFNHNFIL QGSSTNRTKE RKGTTKDLME PALESAVMY
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