E3 ubiquitin-protein ligase TRIM58 (TRIM58)

About E3 ubiquitin-protein ligase TRIM58

E3 ubiquitin-protein ligase TRIM58 (TRIM58) is a protein from Homo sapiens identified by UniProt accession Q8NG06, 486 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase TRIM58
UniProt accession	Q8NG06
Gene	TRIM58
Organism	Homo sapiens
Length	486 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (89)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.50
reticulocyte count · score 0.46
reticulocyte measurement · score 0.43
Red cell distribution width · score 0.43
mean corpuscular volume · score 0.40
mean corpuscular hemoglobin concentration · score 0.40
platelet count · score 0.40
hemoglobin measurement · score 0.39
mean reticulocyte volume · score 0.39
erythrocyte count · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NG06-F1	alphafold	PREDICTED	86.70	—

Amino-acid sequence (486 residues)

MAWAPPGERL REDARCPVCL DFLQEPVSVD CGHSFCLRCI SEFCEKSDGA QGGVYACPQC RGPFRPSGFR PNRQLAGLVE SVRRLGLGAG PGARRCARHG EDLSRFCEED EAALCWVCDA GPEHRTHRTA PLQEAAGSYQ VKLQMALELM RKELEDALTQ EANVGKKTVI WKEKVEMQRQ RFRLEFEKHR GFLAQEEQRQ LRRLEAEERA TLQRLRESKS RLVQQSKALK ELADELQERC QRPALGLLEG VRGVLSRSKA VTRLEAENIP MELKTACCIP GRRELLRKFQ VDVKLDPATA HPSLLLTADL RSVQDGEPWR DVPNNPERFD TWPCILGLQS FSSGRHYWEV LVGEGAEWGL GVCQDTLPRK GETTPSPENG VWALWLLKGN EYMVLASPSV PLLQLESPRC IGIFLDYEAG EISFYNVTDG SYIYTFNQLF SGLLRPYFFI CDATPLILPP TTIAGSGNWA SRDHLDPASD VRDDHL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards