About Tetraspanin-14
Tetraspanin-14 (TSPAN14) is a protein
from Homo sapiens identified by UniProt accession
Q8NG11, 270 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Tetraspanin-14 |
|---|
| UniProt accession | Q8NG11 |
|---|
| Gene | TSPAN14 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 270 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (49)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.33
- inflammatory bowel disease · score 0.31
- Crohn's disease · score 0.29
- myeloid white cell count · score 0.28
- neutrophil count · score 0.26
- asthma · score 0.23
- FEV/FVC ratio · score 0.23
- advanced glycosylation end product-specific receptor ligand measurement · score 0.23
- chronic obstructive pulmonary disease · score 0.22
- coronary artery disease · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NG11-F1 | alphafold | PREDICTED | 88.14 | — |
Amino-acid sequence (270 residues)
MHYYRYSNAK VSCWYKYLLF SYNIIFWLAG VVFLGVGLWA WSEKGVLSDL TKVTRMHGID PVVLVLMVGV VMFTLGFAGC VGALRENICL LNFFCGTIVL IFFLELAVAV LAFLFQDWVR DRFREFFESN IKSYRDDIDL QNLIDSLQKA NQCCGAYGPE DWDLNVYFNC SGASYSREKC GVPFSCCVPD PAQKVVNTQC GYDVRIQLKS KWDESIFTKG CIQALESWLP RNIYIVAGVF IAISLLQIFG IFLARTLISD IEAVKAGHHF
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