About E3 ubiquitin-protein ligase Praja-1
E3 ubiquitin-protein ligase Praja-1 (PJA1) is a protein
from Homo sapiens identified by UniProt accession
Q8NG27, 643 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase Praja-1 |
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| UniProt accession | Q8NG27 |
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| Gene | PJA1 |
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| Organism | Homo sapiens |
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| Length | 643 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (71)
Diseases linked to this target (Open Targets).
- craniofrontonasal syndrome · score 0.23
- Intellectual disability · score 0.23
- Trigonocephaly · score 0.19
- trigonocephaly · score 0.19
- Neurodevelopmental disorder · score 0.19
- Craniofrontonasal dysplasia · score 0.18
- clear cell renal carcinoma · score 0.18
- neoplasm · score 0.08
- hepatocellular carcinoma · score 0.06
- glioblastoma multiforme · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NG27-F1 | alphafold | PREDICTED | 50.12 | — |
Amino-acid sequence (643 residues)
MGQESSKPVW PNPTGGYQSN TGRRYGRRHA YVSFRPPTSQ RERIASQRKT NSEVPMHRSA PSQTTKRSRS PFSTTRRSWD DSESSGTNLN IDNEDYSRYP PREYRASGSR RGMAYGHIDS YGADDSEEEG AGPVERPPVR GKTGKFKDDK LYDPEKGARS LAGPPPHFSS FSRDVREERD KLDPVPAARC SASRADFLPQ SSVASQSSSE GKLATKGDSS ERERREQNLP ARPSRAPVSI CGGGENTSKS AEEPVVRPKI RNLASPNCVK PKIFFDTDDD DDMPHSTSRW RDTANDNEGH SDGLARRGRG ESSSGYPEPK YPEDKREARS DQVKPEKVPR RRRTMADPDF WTHSDDYYKY CDEDSDSDKE WIAALRRKYR SREQTLSSSG ESWETLPGKE EREPPQAKVS ASTGTSPGPG ASASAGAGAG ASAGSNGSNY LEEVREPSLQ EEQASLEEGE IPWLQYHEND SSSEGDNDSG HELMQPGVFM LDGNNNLEDD SSVSEDLEVD WSLFDGFADG LGVAEAISYV DPQFLTYMAL EERLAQAMET ALAHLESLAV DVEVANPPAS KESIDALPEI LVTEDHGAVG QEMCCPICCS EYVKGEVATE LPCHHYFHKP CVSIWLQKSG TCPVCRCMFP PPL
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