Beta-defensin 105 (DEFB105A)

About Beta-defensin 105

Beta-defensin 105 (DEFB105A) is a protein from Homo sapiens identified by UniProt accession Q8NG35, 78 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein name	Beta-defensin 105
UniProt accession	Q8NG35
Gene	DEFB105A
Organism	Homo sapiens
Length	78 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (12)

Diseases linked to this target (Open Targets).

neuroticism measurement · score 0.04
emotional symptom measurement · score 0.02
mastitis · score 0.01
male infertility · score 0.01
silicosis · score 0.01
bacterial disease · score 0.00
neoplasm · score 0.00
mucinous cystadenoma · score 0.00
infect · score 0.00
infection · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NG35-F1	alphafold	PREDICTED	71.01	—

Amino-acid sequence (78 residues)

MALIRKTFYF LFAMFFILVQ LPSGCQAGLD FSQPFPSGEF AVCESCKLGR GKCRKECLEN EKPDGNCRLN FLCCRQRI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards