About Protein Lines homolog 1
Protein Lines homolog 1 (LINS1) is a protein
from Homo sapiens identified by UniProt accession
Q8NG48, 757 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | Protein Lines homolog 1 |
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| UniProt accession | Q8NG48 |
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| Gene | LINS1 |
|---|
| Organism | Homo sapiens |
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| Length | 757 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (89)
Diseases linked to this target (Open Targets).
- intellectual disability, autosomal recessive 27 · score 0.73
- autosomal recessive non-syndromic intellectual disability · score 0.71
- genetic disorder · score 0.39
- complex neurodevelopmental disorder · score 0.37
- PHF-tau measurement · score 0.28
- Intellectual disability · score 0.27
- optic cup area measurement · score 0.15
- chronotype measurement · score 0.15
- cup-to-disc ratio measurement · score 0.15
- chin morphology measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NG48-F1 | alphafold | PREDICTED | 71.36 | — |
Amino-acid sequence (757 residues)
MKVFCEVLEE LYKKVLLGAT LENDSHDYIF YLNPAVSDQD CSTATSLEWA NTCGIQGRHQ PISVGVAPIA VAPVCLKTNS QMSGSREVML LQLTVIKVMT TRILSVKTEF HAKEQYRDVI KILLESAKVD SKLICMFQNS DKLLSHMAAQ CLALLLYFQL REKITLSNSW IAFCQKNLSE YSESNKAIYC LWTLTAIIKE IFKDSCSQKT EILKQFLTHF DTIFEVFYNS LFSQHFENCR DTSKIVNILM CFLDLLELLI ASRIHLKLHF TCQRILFLKP SCMLEVITWP IQAFVKRKVI IFLKKCLLCK VGEDLCRGSV PALMPPDHHV AVDMLALANA VLQAVNSGLL KTLSVYEKHS FFGGDEVQPE CELITSPDHV ILRAASLVIM KSLEIKFQNY SSASEVKVDL QRFMSELLTF LKPHLQPSLQ LHNPCKWLSR VFIEQDDDML EAAKASLGIY LTLTRGCEAT ESLTQGKEMW DHHTHENGYN PHCIFLFFLK NIGFDSTVLL DFLISSETCF LEYFVRYLKL LQKDWDNFFT ICNNFDATES KYDISICGCV PSLVQDQSSN QTIPHRLTAP HSHRDVCARH SWASDAPSEP LKAVMSKGAH TMCASSLSSP RASQSLVDYD SSDDSDVEST EQCLANSKQT SLHQQATKEI QDAAGTSRDK KEFSLEPPSR PLVLKEFDTA FSFDCEVAPN DVVSEVGIFY RIVKCFQELQ DAICRLQKKN LFPYNPTALL KLLKYIEVIS NKTMNTL
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