About Serine/threonine-protein kinase Nek11
Serine/threonine-protein kinase Nek11 (NEK11) is a protein
from Homo sapiens identified by UniProt accession
Q8NG66, 645 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase Nek11 |
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| UniProt accession | Q8NG66 |
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| Gene | NEK11 |
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| Organism | Homo sapiens |
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| Length | 645 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (47)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- hip bone mineral density · score 0.26
- hip bone size · score 0.26
- smoking status measurement · score 0.23
- fat body mass · score 0.21
- smoking behavior · score 0.17
- smoking behaviour measurement · score 0.12
- protein measurement · score 0.08
- Age-related cataract · score 0.07
- breast cancer · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NG66-F1 | alphafold | PREDICTED | 68.29 | — |
Amino-acid sequence (645 residues)
MLKFQEAAKC VSGSTAISTY PKTLIARRYV LQQKLGSGSF GTVYLVSDKK AKRGEELKVL KEISVGELNP NETVQANLEA QLLSKLDHPA IVKFHASFVE QDNFCIITEY CEGRDLDDKI QEYKQAGKIF PENQIIEWFI QLLLGVDYMH ERRILHRDLK SKNVFLKNNL LKIGDFGVSR LLMGSCDLAT TLTGTPHYMS PEALKHQGYD TKSDIWSLAC ILYEMCCMNH AFAGSNFLSI VLKIVEGDTP SLPERYPKEL NAIMESMLNK NPSLRPSAIE ILKIPYLDEQ LQNLMCRYSE MTLEDKNLDC QKEAAHIINA MQKRIHLQTL RALSEVQKMT PRERMRLRKL QAADEKARKL KKIVEEKYEE NSKRMQELRS RNFQQLSVDV LHEKTHLKGM EEKEEQPEGR LSCSPQDEDE ERWQGREEES DEPTLENLPE SQPIPSMDLH ELESIVEDAT SDLGYHEIPE DPLVAEEYYA DAFDSYCEES DEEEEEIALE RPEKEIRNEG SQPAYRTNQQ DSDIEALARC LENVLGCTSL DTKTITTMAE DMSPGPPIFN SVMARTKMKR MRESAMQKLG TEVFEEVYNY LKRARHQNAS EAEIRECLEK VVPQASDCFE VDQLLYFEEQ LLITMGKEPT LQNHL
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