About Tubulin--tyrosine ligase
Tubulin--tyrosine ligase (TTL) is a protein
from Homo sapiens identified by UniProt accession
Q8NG68, 377 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | Tubulin--tyrosine ligase |
|---|
| UniProt accession | Q8NG68 |
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| Gene | TTL |
|---|
| Organism | Homo sapiens |
|---|
| Length | 377 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (59)
Diseases linked to this target (Open Targets).
- smoking status measurement · score 0.34
- alcohol consumption measurement · score 0.21
- smoking behaviour measurement · score 0.20
- smoking initiation · score 0.20
- attention deficit hyperactivity disorder · score 0.19
- antisocial behaviour measurement · score 0.19
- substance abuse · score 0.19
- neuroticism measurement · score 0.15
- protein measurement · score 0.10
- neoplasm · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NG68-F1 | alphafold | PREDICTED | 92.63 | — |
Amino-acid sequence (377 residues)
MYTFVVRDEN SSVYAEVSRL LLATGHWKRL RRDNPRFNLM LGERNRLPFG RLGHEPGLVQ LVNYYRGADK LCRKASLVKL IKTSPELAES CTWFPESYVI YPTNLKTPVA PAQNGIQPPI SNSRTDEREF FLASYNRKKE DGEGNVWIAK SSAGAKGEGI LISSEASELL DFIDNQGQVH VIQKYLEHPL LLEPGHRKFD IRSWVLVDHQ YNIYLYREGV LRTASEPYHV DNFQDKTCHL TNHCIQKEYS KNYGKYEEGN EMFFKEFNQY LTSALNITLE SSILLQIKHI IRNCLLSVEP AISTKHLPYQ SFQLFGFDFM VDEELKVWLI EVNGAPACAQ KLYAELCQGI VDIAISSVFP PPDVEQPQTQ PAAFIKL
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