About Olfactory receptor 5AR1
Olfactory receptor 5AR1 (OR5AR1) is a protein
from Homo sapiens identified by UniProt accession
Q8NGP9, 310 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Olfactory receptor 5AR1 |
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| UniProt accession | Q8NGP9 |
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| Gene | OR5AR1 |
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| Organism | Homo sapiens |
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| Length | 310 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- neuroblastoma · score 0.21
- clear cell renal carcinoma · score 0.18
- breast adenocarcinoma · score 0.18
- acute myeloid leukemia · score 0.14
- inflammatory bowel disease · score 0.12
- major depressive disorder · score 0.08
- obsessive-compulsive disorder · score 0.07
- unipolar depression · score 0.03
- smoking behaviour measurement · score 0.03
- hypertrophic cardiomyopathy · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NGP9-F1 | alphafold | PREDICTED | 90.95 | — |
Amino-acid sequence (310 residues)
MDKENSSMVT EFIFMGITQD PQMEIIFFVV FLIVYLVNVV GNIGMIILIT TDTQLHTPMY FFLCNLSFVD LGYSSAIAPR MLADFLTNHK VISFSSCATQ FAFFVGFVDA ECYVLAAMAY GRFVAICRPL HYSTFMSKQV CLALMLGSYL AGLVSLVAHT TLTFSLSYCG SNIINHFFCE IPPLLALSCS DTYISEILLF SLCGFIEFST ILIIFISYTF ILVAIIRMRS AEGRLKAFST CGSHLTGITL FYGTVMFMYL RPTSSYSLDQ DKWASVFYTV IIPMLNPLIY SLRNKDVKAA FKKLIGKKSQ
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