Olfactory receptor 2AE1 (OR2AE1)

About Olfactory receptor 2AE1

Olfactory receptor 2AE1 (OR2AE1) is a protein from Homo sapiens identified by UniProt accession Q8NHA4, 323 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.

Target properties

Protein name	Olfactory receptor 2AE1
UniProt accession	Q8NHA4
Gene	OR2AE1
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (15)

Diseases linked to this target (Open Targets).

hematocrit · score 0.37
mean corpuscular hemoglobin concentration · score 0.37
hemoglobin measurement · score 0.37
erythrocyte count · score 0.34
prostate adenocarcinoma · score 0.18
breast adenocarcinoma · score 0.18
HbA1c measurement · score 0.16
lymphocyte count · score 0.07
serum metabolite measurement · score 0.06
metabolite measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NHA4-F1	alphafold	PREDICTED	86.27	—

Amino-acid sequence (323 residues)

MWQKNQTSLA DFILEGLFDD SLTHLFLFSL TMVVFLIAVS GNTLTILLIC IDPQLHTPMY FLLSQLSLMD LMHVSTIILK MATNYLSGKK SISFVGCATQ HFLYLCLGGA ECFLLAVMSY DRYVAICHPL RYAVLMNKKV GLMMAVMSWL GASVNSLIHM AILMHFPFCG PRKVYHFYCE FPAVVKLVCG DITVYETTVY ISSILLLLPI FLISTSYVFI LQSVIQMRSS GSKRNAFATC GSHLTVVSLW FGACIFSYMR PRSQCTLLQN KVGSVFYSII TPTLNSLIYT LRNKDVAKAL RRVLRRDVIT QCIQRLQLWL PRV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards