V-type proton ATPase subunit e 2 (ATP6V0E2)

About V-type proton ATPase subunit e 2

V-type proton ATPase subunit e 2 (ATP6V0E2) is a protein from Homo sapiens identified by UniProt accession Q8NHE4, 81 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.

Target properties

Protein name	V-type proton ATPase subunit e 2
UniProt accession	Q8NHE4
Gene	ATP6V0E2
Organism	Homo sapiens
Length	81 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (15)

Diseases linked to this target (Open Targets).

drug use measurement · score 0.31
adolescent idiopathic scoliosis · score 0.16
reticulocyte count · score 0.02
clear cell renal carcinoma · score 0.02
bacteriemia · score 0.01
psoriasis · score 0.01
transitional cell carcinoma of kidney · score 0.01
septic shock · score 0.00
cystic fibrosis · score 0.00
mucocutaneous lymph node syndrome · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NHE4-F1	alphafold	PREDICTED	94.68	—

Amino-acid sequence (81 residues)

MTAHSFALPV IIFTTFWGLV GIAGPWFVPK GPNRGVIITM LVATAVCCYL FWLIAILAQL NPLFGPQLKN ETIWYVRFLW E

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards