About E3 ubiquitin-protein ligase ZNRF2
E3 ubiquitin-protein ligase ZNRF2 (ZNRF2) is a protein
from Homo sapiens identified by UniProt accession
Q8NHG8, 242 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase ZNRF2 |
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| UniProt accession | Q8NHG8 |
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| Gene | ZNRF2 |
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| Organism | Homo sapiens |
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| Length | 242 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (32)
Diseases linked to this target (Open Targets).
- inflammatory biomarker measurement · score 0.30
- YKL40 measurement · score 0.30
- serum gamma-glutamyl transferase measurement · score 0.24
- neoplasm · score 0.08
- cancer · score 0.06
- hepatocellular carcinoma · score 0.05
- osteosarcoma · score 0.05
- non-small cell lung carcinoma · score 0.04
- breast cancer · score 0.03
- pancreatic adenocarcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NHG8-F1 | alphafold | PREDICTED | 65.61 | — |
Amino-acid sequence (242 residues)
MGAKQSGPAA ANGRTRAYSG SDLPSSSSGG ANGTAGGGGG ARAAAAGRFP AQVPSAHQPS ASGGAAAAAA APAAPAAPRS RSLGGAVGSV ASGARAAQSP FSIPNSSSGP YGSQDSVHSS PEDGGGGRDR PVGGSPGGPR LVIGSLPAHL SPHMFGGFKC PVCSKFVSSD EMDLHLVMCL TKPRITYNED VLSKDAGECA ICLEELQQGD TIARLPCLCI YHKGCIDEWF EVNRSCPEHP SD
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