About Leukocyte immunoglobulin-like receptor subfamily B member 4
Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is a protein
from Homo sapiens identified by UniProt accession
Q8NHJ6, 448 residues long.
MolForge cross-references it against 0 known binders and
301 disease associations.
Target properties
| Protein name | Leukocyte immunoglobulin-like receptor subfamily B member 4 |
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| UniProt accession | Q8NHJ6 |
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| Gene | LILRB4 |
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| Organism | Homo sapiens |
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| Length | 448 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (301)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.25
- blood protein measurement · score 0.21
- inflammatory bowel disease · score 0.17
- neoplasm · score 0.11
- acute myeloid leukemia · score 0.11
- toxoplasmosis · score 0.09
- Miyoshi myopathy · score 0.08
- multiple myeloma · score 0.08
- hypertrophic cardiomyopathy · score 0.08
- chronic obstructive pulmonary disease · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NHJ6-F1 | alphafold | PREDICTED | 65.88 | — |
Amino-acid sequence (448 residues)
MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ GTLEAREYRL DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY RSPVGWSQPS DPLELVMTGA YSKPTLSALP SPLVTSGKSV TLLCQSRSPM DTFLLIKERA AHPLLHLRSE HGAQQHQAEF PMSPVTSVHG GTYRCFSSHG FSHYLLSHPS DPLELIVSGS LEDPRPSPTR SVSTAAGPED QPLMPTGSVP HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR PPGAAEPEPK DGGLQRRSSP AADVQGENFC AAVKNTQPED GVEMDTRQSP HDEDPQAVTY AKVKHSRPRR EMASPPSPLS GEFLDTKDRQ AEEDRQMDTE AAASEAPQDV TYAQLHSFTL RQKATEPPPS QEGASPAEPS VYATLAIH
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