About Centrosomal protein of 70 kDa
Centrosomal protein of 70 kDa (CEP70) is a protein
from Homo sapiens identified by UniProt accession
Q8NHQ1, 597 residues long.
MolForge cross-references it against 0 known binders and
159 disease associations.
Target properties
| Protein name | Centrosomal protein of 70 kDa |
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| UniProt accession | Q8NHQ1 |
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| Gene | CEP70 |
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| Organism | Homo sapiens |
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| Length | 597 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (159)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.31
- testosterone measurement · score 0.26
- bone density · score 0.23
- urate measurement · score 0.23
- breast adenocarcinoma · score 0.23
- azoospermia · score 0.10
- Female infertility due to fertilization defect · score 0.09
- Rare genetic female infertility · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NHQ1-F1 | alphafold | PREDICTED | 76.80 | — |
Amino-acid sequence (597 residues)
MFPVAPKPQD SSQPSDRLMT EKQQEEAEWE SINVLLMMHG LKPLSLVKRT DLKDLIIFDK QSSQRMRQNL KLLVEETSCQ QNMIQELIET NQQLRNELQL EQSRAANQEQ RANDLEQIME SVKSKIGELE DESLSRACHQ QNKIKDLQKE QKTLQVKCQH YKKKRTEQEE TIASLQMEVC RLKKEEEDRI VTQNRVFAYL CKRVPHTVLD RQLLCLIDYY ESKIRKIHTQ RQYKEDESQS EEENDYRNLD ASPTYKGLLM SLQNQLKESK SKIDALSSEK LNLQKDLETR PTQHELRLYK QQVKKLEKAL KKNVKLQELI NHKKAEDTEK KDEPSKYNQQ QALIDQRYFQ VLCSINSIIH NPRAPVIIYK QTKGGVQNFN KDLVQDCGFE HLVPVIEMWA DQLTSLKDLY KSLKTLSAEL VPWLNLKKQD ENEGIKVEDL LFIVDTMLEE VENKEKDSNM PHFQTLQAIV SHFQKLFDVP SLNGVYPRMN EVYTRLGEMN NAVRNLQELL ELDSSSSLCV LVSTVGKLCR LINEDVNEQV MQVLGPEDLQ SIIYKLEEHE EFFPAFQAFT NDLLEILEID DLDAIVPAVK KLKVLSY
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