Ras association domain-containing protein 8 (RASSF8)

About Ras association domain-containing protein 8

Ras association domain-containing protein 8 (RASSF8) is a protein from Homo sapiens identified by UniProt accession Q8NHQ8, 419 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	Ras association domain-containing protein 8
UniProt accession	Q8NHQ8
Gene	RASSF8
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

body height · score 0.35
PHF-tau measurement · score 0.34
heel bone mineral density · score 0.32
neurofibrillary tangles measurement · score 0.28
diffuse plaque measurement · score 0.25
bone disease · score 0.24
neurodegenerative disease · score 0.24
bone quantitative ultrasound measurement · score 0.19
esophageal squamous cell carcinoma · score 0.10
melanoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NHQ8-F1	alphafold	PREDICTED	75.91	—

Amino-acid sequence (419 residues)

MELKVWVDGV QRIVCGVTEV TTCQEVVIAL AQAIGRTGRY TLIEKWRDTE RHLAPHENPI ISLNKWGQYA SDVQLILRRT GPSLSERPTS DSVARIPERT LYRQSLPPLA KLRPQIDKSI KRREPKRKSL TFTGGAKGLM DIFGKGKETE FKQKVLNNCK TTADELKKLI RLQTEKLQSI EKQLESNEIE IRFWEQKYNS NLEEEIVRLE QKIKRNDVEI EEEEFWENEL QIEQENEKQL KDQLQEIRQK ITECENKLKD YLAQIRTMES GLEAEKLQRE VQEAQVNEEE VKGKIGKVKG EIDIQGQQSL RLENGIKAVE RSLGQATKRL QDKEQELEQL TKELRQVNLQ QFIQQTGTKV TVLPAEPIEI EASHADIERE APFQSGSLKR PGSSRQLPSN LRILQNPISS GFNPEGIYV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards