About ATP-dependent RNA helicase DDX55
ATP-dependent RNA helicase DDX55 (DDX55) is a protein
from Homo sapiens identified by UniProt accession
Q8NHQ9, 600 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | ATP-dependent RNA helicase DDX55 |
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| UniProt accession | Q8NHQ9 |
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| Gene | DDX55 |
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| Organism | Homo sapiens |
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| Length | 600 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (34)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.25
- leukocyte count · score 0.22
- lymphocyte count · score 0.22
- myeloid white cell count · score 0.19
- hepatocellular carcinoma · score 0.07
- Blackfan-Diamond anemia · score 0.05
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.05
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.05
- hemoglobin D disease · score 0.04
- Heinz body anemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NHQ9-F1 | alphafold | PREDICTED | 84.40 | — |
Amino-acid sequence (600 residues)
MEHVTEGSWE SLPVPLHPQV LGALRELGFP YMTPVQSATI PLFMRNKDVA AEAVTGSGKT LAFVIPILEI LLRREEKLKK SQVGAIIITP TRELAIQIDE VLSHFTKHFP EFSQILWIGG RNPGEDVERF KQQGGNIIVA TPGRLEDMFR RKAEGLDLAS CVRSLDVLVL DEADRLLDMG FEASINTILE FLPKQRRTGL FSATQTQEVE NLVRAGLRNP VRVSVKEKGV AASSAQKTPS RLENYYMVCK ADEKFNQLVH FLRNHKQEKH LVFFSTCACV EYYGKALEVL VKGVKIMCIH GKMKYKRNKI FMEFRKLQSG ILVCTDVMAR GIDIPEVNWV LQYDPPSNAS AFVHRCGRTA RIGHGGSALV FLLPMEESYI NFLAINQKCP LQEMKPQRNT ADLLPKLKSM ALADRAVFEK GMKAFVSYVQ AYAKHECNLI FRLKDLDFAS LARGFALLRM PKMPELRGKQ FPDFVPVDVN TDTIPFKDKI REKQRQKLLE QQRREKTENE GRRKFIKNKA WSKQKAKKEK KKKMNEKRKR EEGSDIEDED MEELLNDTRL LKKLKKGKIT EEEFEKGLLT TGKRTIKTVD LGISDLEDDC
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