About Major facilitator superfamily domain-containing protein 8
Major facilitator superfamily domain-containing protein 8 (MFSD8) is a protein
from Homo sapiens identified by UniProt accession
Q8NHS3, 518 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | Major facilitator superfamily domain-containing protein 8 |
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| UniProt accession | Q8NHS3 |
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| Gene | MFSD8 |
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| Organism | Homo sapiens |
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| Length | 518 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (109)
Diseases linked to this target (Open Targets).
- neuronal ceroid lipofuscinosis 7 · score 0.84
- CLN7 disease · score 0.81
- macular dystrophy with central cone involvement · score 0.73
- neuronal ceroid lipofuscinosis · score 0.59
- age-related macular degeneration · score 0.56
- genetic disorder · score 0.53
- late infantile neuronal ceroid lipofuscinosis · score 0.52
- Retinal dystrophy · score 0.35
- autosomal recessive primary microcephaly · score 0.34
- retinitis pigmentosa · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NHS3-F1 | alphafold | PREDICTED | 83.30 | — |
Amino-acid sequence (518 residues)
MAGLRNESEQ EPLLGDTPGS REWDILETEE HYKSRWRSIR ILYLTMFLSS VGFSVVMMSI WPYLQKIDPT ADTSFLGWVI ASYSLGQMVA SPIFGLWSNY RPRKEPLIVS ILISVAANCL YAYLHIPASH NKYYMLVARG LLGIGAGNVA VVRSYTAGAT SLQERTSSMA NISMCQALGF ILGPVFQTCF TFLGEKGVTW DVIKLQINMY TTPVLLSAFL GILNIILILA ILREHRVDDS GRQCKSINFE EASTDEAQVP QGNIDQVAVV AINVLFFVTL FIFALFETII TPLTMDMYAW TQEQAVLYNG IILAALGVEA VVIFLGVKLL SKKIGERAIL LGGLIVVWVG FFILLPWGNQ FPKIQWEDLH NNSIPNTTFG EIIIGLWKSP MEDDNERPTG CSIEQAWCLY TPVIHLAQFL TSAVLIGLGY PVCNLMSYTL YSKILGPKPQ GVYMGWLTAS GSGARILGPM FISQVYAHWG PRWAFSLVCG IIVLTITLLG VVYKRLIALS VRYGRIQE
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