About Clathrin heavy chain linker domain-containing protein 1
Clathrin heavy chain linker domain-containing protein 1 (CLHC1) is a protein
from Homo sapiens identified by UniProt accession
Q8NHS4, 586 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | Clathrin heavy chain linker domain-containing protein 1 |
|---|
| UniProt accession | Q8NHS4 |
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| Gene | CLHC1 |
|---|
| Organism | Homo sapiens |
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| Length | 586 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (23)
Diseases linked to this target (Open Targets).
- brain measurement · score 0.29
- neurofibrillary tangles measurement · score 0.27
- Waddling gait · score 0.26
- mean corpuscular hemoglobin concentration · score 0.18
- body height · score 0.13
- metabolite measurement · score 0.06
- lymphocyte count · score 0.03
- urate measurement · score 0.03
- body fat percentage · score 0.02
- lean body mass · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NHS4-F1 | alphafold | PREDICTED | 81.84 | — |
Amino-acid sequence (586 residues)
MSVHQIRKHA VLPPIICRSD KEFLESVQRY IITETERLGC SEEGPADEYY IIYRNVFDKV IEHITAYKSI LTSIKKEYDA FIETIKKDRR TTFCLHGKLK GLAAEPTALV YYRKRTIQLE AKMRIIESNS SKIQSQIDHI KQCRAEYDTK EVKYCTFSKD PSKPIPGMTL QESMNLDALT KYMKHLEDKY AEIKQAMLIK YVPAQRKADL DEEMIVLLKR RDVAENLNKK LQFCHQRLQI ISQALSSWVK SDMSSPFQDF VEQIQKTKYL QGDQGIVEEL MEDDPRRAKE AEIMLHYIER FNELISLGEY EKAACYAANS PRRILRNIGT MNTFKAVGKI RGKPLPLLLF FEALFITSHA FPCPVDAALT LEGIKCGLSE KRLDLVTNWV TQERLTFSEE AGDVICDYGE QDTYNKAKCL ALAQIVYSEC GLHKKAILCL CKQGQTHRVM EYIQQLKDFT TDDLLQLLMS CPQVELIQCL TKELNEKQPS LSFGLAILHL FSADMKKVGI KLLQEINKGG IDAVESLMIN DSFCSIEKWQ EVANICSQNG FDKLSNDITS ILRSQAAVTE ISEEDDAVNL MEHVFW
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