Spermatogenesis-associated protein 22 (SPATA22)

About Spermatogenesis-associated protein 22

Spermatogenesis-associated protein 22 (SPATA22) is a protein from Homo sapiens identified by UniProt accession Q8NHS9, 363 residues long. MolForge cross-references it against 0 known binders and 170 disease associations.

Target properties

Protein name	Spermatogenesis-associated protein 22
UniProt accession	Q8NHS9
Gene	SPATA22
Organism	Homo sapiens
Length	363 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (170)

Diseases linked to this target (Open Targets).

Canavan disease · score 0.58
genetic disorder · score 0.53
mild Canavan disease · score 0.42
neurodegenerative disease · score 0.37
Abnormality of metabolism/homeostasis · score 0.27
pathological myopia · score 0.21
Non-epidermolytic palmoplantar keratoderma · score 0.19
Olmsted syndrome 1 · score 0.18
Intellectual disability · score 0.11
Fraser syndrome · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NHS9-F1	alphafold	PREDICTED	60.57	—

Amino-acid sequence (363 residues)

MKRSLNENSA RSTAGCLPVP LFNQKKRNRQ PLTSNPLKDD SGISTPSDNY DFPPLPTDWA WEAVNPELAP VMKTVDTGQI PHSVSRPLRS QDSVFNSIQS NTGRSQGGWS YRDGNKNTSL KTWNKNDFKP QCKRTNLVAN DGKNSCPVSS GAQQQKQLRI PEPPNLSRNK ETELLRQTHS SKISGCTMRG LDKNSALQTL KPNFQQNQYK KQMLDDIPED NTLKETSLYQ LQFKEKASSL RIISAVIESM KYWREHAQKT VLLFEVLAVL DSAVTPGPYY SKTFLMRDGK NTLPCVFYEI DRELPRLIRG RVHRCVGNYD QKKNIFQCVS VRPASVSEQK TFQAFVKIAD VEMQYYINVM NET

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards