About Phosphatidylcholine:ceramide cholinephosphotransferase 2
Phosphatidylcholine:ceramide cholinephosphotransferase 2 (SGMS2) is a protein
from Homo sapiens identified by UniProt accession
Q8NHU3, 365 residues long.
MolForge cross-references it against 0 known binders and
139 disease associations.
Target properties
| Protein name | Phosphatidylcholine:ceramide cholinephosphotransferase 2 |
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| UniProt accession | Q8NHU3 |
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| Gene | SGMS2 |
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| Organism | Homo sapiens |
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| Length | 365 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (139)
Diseases linked to this target (Open Targets).
- calvarial doughnut lesions-bone fragility syndrome · score 0.65
- Calvarial doughnut lesions - bone fragility · score 0.56
- calvarial doughnut lesions with bone fragility and spondylometaphyseal dysplasia · score 0.42
- genetic disorder · score 0.33
- neurodegenerative disease · score 0.27
- PHF-tau measurement · score 0.18
- protein measurement · score 0.16
- Osteopenia · score 0.09
- pancreatic neoplasm · score 0.07
- Platelet-activating factor acetylhydrolase deficiency · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NHU3-F1 | alphafold | PREDICTED | 76.76 | — |
Amino-acid sequence (365 residues)
MDIIETAKLE EHLENQPSDP TNTYARPAEP VEEENKNGNG KPKSLSSGLR KGTKKYPDYI QIAMPTESRN KFPLEWWKTG IAFIYAVFNL VLTTVMITVV HERVPPKELS PPLPDKFFDY IDRVKWAFSV SEINGIILVG LWITQWLFLR YKSIVGRRFC FIIGTLYLYR CITMYVTTLP VPGMHFQCAP KLNGDSQAKV QRILRLISGG GLSITGSHIL CGDFLFSGHT VTLTLTYLFI KEYSPRHFWW YHLICWLLSA AGIICILVAH EHYTIDVIIA YYITTRLFWW YHSMANEKNL KVSSQTNFLS RAWWFPIFYF FEKNVQGSIP CCFSWPLSWP PGCFKSSCKK YSRVQKIGED NEKST
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