Transcription factor MafA (MAFA)

About Transcription factor MafA

Transcription factor MafA (MAFA) is a protein from Homo sapiens identified by UniProt accession Q8NHW3, 353 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.

Target properties

Protein name	Transcription factor MafA
UniProt accession	Q8NHW3
Gene	MAFA
Organism	Homo sapiens
Length	353 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (68)

Diseases linked to this target (Open Targets).

islet cell adenomatosis · score 0.53
high density lipoprotein cholesterol measurement · score 0.22
juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome · score 0.12
MODY · score 0.10
apolipoprotein A 1 measurement · score 0.09
type 2 diabetes mellitus · score 0.08
type 1 diabetes mellitus · score 0.08
hyperinsulinism due to INSR deficiency · score 0.07
hyperinsulinism due to glucokinase deficiency · score 0.07
diabetes mellitus, transient neonatal, 2 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NHW3-F1	alphafold	PREDICTED	61.54	—

Amino-acid sequence (353 residues)

MAAELAMGAE LPSSPLAIEY VNDFDLMKFE VKKEPPEAER FCHRLPPGSL SSTPLSTPCS SVPSSPSFCA PSPGTGGGGG AGGGGGSSQA GGAPGPPSGG PGAVGGTSGK PALEDLYWMS GYQHHLNPEA LNLTPEDAVE ALIGSGHHGA HHGAHHPAAA AAYEAFRGPG FAGGGGADDM GAGHHHGAHH AAHHHHAAHH HHHHHHHHGG AGHGGGAGHH VRLEERFSDD QLVSMSVREL NRQLRGFSKE EVIRLKQKRR TLKNRGYAQS CRFKRVQQRH ILESEKCQLQ SQVEQLKLEV GRLAKERDLY KEKYEKLAGR GGPGSAGGAG FPREPSPPQA GPGGAKGTAD FFL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards