About Spermatogenesis-associated protein 3
Spermatogenesis-associated protein 3 (SPATA3) is a protein
from Homo sapiens identified by UniProt accession
Q8NHX4, 192 residues long.
MolForge cross-references it against 0 known binders and
73 disease associations.
Target properties
| Protein name | Spermatogenesis-associated protein 3 |
|---|
| UniProt accession | Q8NHX4 |
|---|
| Gene | SPATA3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 192 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (73)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- partial chromosome Y deletion · score 0.07
- spermatogenic failure 20 · score 0.07
- spermatogenic failure 72 · score 0.07
- spermatogenic failure 18 · score 0.07
- spermatogenic failure 46 · score 0.07
- spermatogenic failure 27 · score 0.07
- spermatogenic failure 5 · score 0.06
- spermatogenic failure 51 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NHX4-F1 | alphafold | PREDICTED | 52.66 | — |
Amino-acid sequence (192 residues)
MKKVKKKRSE ARRHRDSTSQ HASSNSTSQQ PSPESTPQQP SPESTPQQPS PESTPQHSSL ETTSRQPAFQ ALPAPEIRRS SCCLLSPDAN VKAAPQSRKA GPLIRAGPHS CSCATCPCSS ACWRRLGLCH SRIFDVLLPR DWQMAPGRGL PNLLTFYRKS SRKPSSHRNA CPPSPRNCGC GSGGSRSCLL HH
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