About Checkpoint protein HUS1B
Checkpoint protein HUS1B (HUS1B) is a protein
from Homo sapiens identified by UniProt accession
Q8NHY5, 278 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Checkpoint protein HUS1B |
|---|
| UniProt accession | Q8NHY5 |
|---|
| Gene | HUS1B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 278 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- intraocular pressure measurement · score 0.24
- FEV/FVC ratio · score 0.24
- glaucoma · score 0.22
- open-angle glaucoma · score 0.21
- mean corpuscular hemoglobin concentration · score 0.20
- Antiglaucoma preparations and miotics use measurement · score 0.20
- sunburn · score 0.19
- eosinophil count · score 0.18
- mean corpuscular hemoglobin · score 0.18
- eosinophil percentage of leukocytes · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NHY5-F1 | alphafold | PREDICTED | 89.32 | — |
Amino-acid sequence (278 residues)
MKFRAKITGK GCLELFIHVS GTVARLAKVC VLRVRPDSLC FGPAGSGGLH EARLWCEVRQ GAFQQFRMEG VSEDLDEIHL ELTAEHLSRA ARSAAGASSL KLQLTHKRRP SLTVAVELVS SLGRARSVVH DLPVRVLPRR VWRDCLPPSL RASDASIRLP RWRTLRSIVE RMANVGSHVL VEANLSGRMT LSIETEVVSI QSYFKNLGNP PQSAVGVPEN RDLESMVQVR VDNRKLLQFL EGQQIHPTTA LCNIWDNTLL QLVLVQEDVS LQYFIPAL
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