About Zinc finger protein 28 homolog
Zinc finger protein 28 homolog (ZFP28) is a protein
from Homo sapiens identified by UniProt accession
Q8NHY6, 868 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Zinc finger protein 28 homolog |
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| UniProt accession | Q8NHY6 |
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| Gene | ZFP28 |
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| Organism | Homo sapiens |
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| Length | 868 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.19
- apolipoprotein B measurement · score 0.16
- lymphocyte count · score 0.16
- low density lipoprotein cholesterol measurement · score 0.16
- body height · score 0.11
- Blackfan-Diamond anemia · score 0.09
- attention deficit hyperactivity disorder · score 0.07
- antisocial behaviour measurement · score 0.07
- substance abuse · score 0.07
- primary familial polycythemia due to EPO receptor mutation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NHY6-F1 | alphafold | PREDICTED | 58.63 | — |
Amino-acid sequence (868 residues)
MRGAASASVR EPTPLPGRGA PRTKPRAGRG PTVGTPATLA LPARGRPRSR NGLASKGQRG AAPTGPGHRA LPSRDTALPQ ERNKKLEAVG TGIEPKAMSQ GLVTFGDVAV DFSQEEWEWL NPIQRNLYRK VMLENYRNLA SLGLCVSKPD VISSLEQGKE PWTVKRKMTR AWCPDLKAVW KIKELPLKKD FCEGKLSQAV ITERLTSYNL EYSLLGEHWD YDALFETQPG LVTIKNLAVD FRQQLHPAQK NFCKNGIWEN NSDLGSAGHC VAKPDLVSLL EQEKEPWMVK RELTGSLFSG QRSVHETQEL FPKQDSYAEG VTDRTSNTKL DCSSFRENWD SDYVFGRKLA VGQETQFRQE PITHNKTLSK ERERTYNKSG RWFYLDDSEE KVHNRDSIKN FQKSSVVIKQ TGIYAGKKLF KCNECKKTFT QSSSLTVHQR IHTGEKPYKC NECGKAFSDG SSFARHQRCH TGKKPYECIE CGKAFIQNTS LIRHWRYYHT GEKPFDCIDC GKAFSDHIGL NQHRRIHTGE KPYKCDVCHK SFRYGSSLTV HQRIHTGEKP YECDVCRKAF SHHASLTQHQ RVHSGEKPFK CKECGKAFRQ NIHLASHLRI HTGEKPFECA ECGKSFSISS QLATHQRIHT GEKPYECKVC SKAFTQKAHL AQHQKTHTGE KPYECKECGK AFSQTTHLIQ HQRVHTGEKP YKCMECGKAF GDNSSCTQHQ RLHTGQRPYE CIECGKAFKT KSSLICHRRS HTGEKPYECS VCGKAFSHRQ SLSVHQRIHS GKKPYECKEC RKTFIQIGHL NQHKRVHTGE RSYNYKKSRK VFRQTAHLAH HQRIHTGESS TCPSLPSTSN PVDLFPKFLW NPSSLPSP
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