About Interleukin-31 receptor subunit alpha
Interleukin-31 receptor subunit alpha (IL31RA) is a protein
from Homo sapiens identified by UniProt accession
Q8NI17, 732 residues long.
MolForge cross-references it against 0 known binders and
282 disease associations.
Target properties
| Protein name | Interleukin-31 receptor subunit alpha |
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| UniProt accession | Q8NI17 |
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| Gene | IL31RA |
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| Organism | Homo sapiens |
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| Length | 732 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (282)
Diseases linked to this target (Open Targets).
- familial primary localized cutaneous amyloidosis · score 0.45
- prurigo nodularis · score 0.37
- lymphocyte count · score 0.37
- leukocyte count · score 0.37
- atopic eczema · score 0.36
- dermatitis · score 0.26
- rheumatic disease · score 0.16
- systemic scleroderma · score 0.09
- neutrophil count · score 0.09
- dermatitis, atopic · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NI17-F1 | alphafold | PREDICTED | 74.03 | — |
Amino-acid sequence (732 residues)
MMWTWALWML PSLCKFSLAA LPAKPENISC VYYYRKNLTC TWSPGKETSY TQYTVKRTYA FGEKHDNCTT NSSTSENRAS CSFFLPRITI PDNYTIEVEA ENGDGVIKSH MTYWRLENIA KTEPPKIFRV KPVLGIKRMI QIEWIKPELA PVSSDLKYTL RFRTVNSTSW MEVNFAKNRK DKNQTYNLTG LQPFTEYVIA LRCAVKESKF WSDWSQEKMG MTEEEAPCGL ELWRVLKPAE ADGRRPVRLL WKKARGAPVL EKTLGYNIWY YPESNTNLTE TMNTTNQQLE LHLGGESFWV SMISYNSLGK SPVATLRIPA IQEKSFQCIE VMQACVAEDQ LVVKWQSSAL DVNTWMIEWF PDVDSEPTTL SWESVSQATN WTIQQDKLKP FWCYNISVYP MLHDKVGEPY SIQAYAKEGV PSEGPETKVE NIGVKTVTIT WKEIPKSERK GIICNYTIFY QAEGGKGFSK TVNSSILQYG LESLKRKTSY IVQVMASTSA GGTNGTSINF KTLSFSVFEI ILITSLIGGG LLILIILTVA YGLKKPNKLT HLCWPTVPNP AESSIATWHG DDFKDKLNLK ESDDSVNTED RILKPCSTPS DKLVIDKLVV NFGNVLQEIF TDEARTGQEN NLGGEKNGYV TCPFRPDCPL GKSFEELPVS PEIPPRKSQY LRSRMPEGTR PEAKEQLLFS GQSLVPDHLC EEGAPNPYLK NSVTAREFLV SEKLPEHTKG EV
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