About Multiple coagulation factor deficiency protein 2
Multiple coagulation factor deficiency protein 2 (MCFD2) is a protein
from Homo sapiens identified by UniProt accession
Q8NI22, 146 residues long.
MolForge cross-references it against 0 known binders and
60 disease associations.
Target properties
| Protein name | Multiple coagulation factor deficiency protein 2 |
|---|
| UniProt accession | Q8NI22 |
|---|
| Gene | MCFD2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 146 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (60)
Diseases linked to this target (Open Targets).
- combined deficiency of factor V and factor VIII · score 0.66
- neurodegenerative disease · score 0.53
- factor V and factor VIII, combined deficiency of, type 1 · score 0.46
- multiple intestinal atresia · score 0.45
- neuroinflammatory disorder · score 0.33
- platelet count · score 0.31
- Thrombocytopenia · score 0.29
- Abnormal bleeding · score 0.29
- severe combined immunodeficiency · score 0.27
- mean reticulocyte volume · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NI22-F1 | alphafold | PREDICTED | 76.18 | — |
Amino-acid sequence (146 residues)
MTMRSLLRTP FLCGLLWAFC APGARAEEPA ASFSQPGSMG LDKNTVHDQE HIMEHLEGVI NKPEAEMSPQ ELQLHYFKMH DYDGNNLLDG LELSTAITHV HKEEGSEQAP LMSEDELINI IDGVLRDDDK NNDGYIDYAE FAKSLQ
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