About F-box only protein 27
F-box only protein 27 (FBXO27) is a protein
from Homo sapiens identified by UniProt accession
Q8NI29, 283 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | F-box only protein 27 |
|---|
| UniProt accession | Q8NI29 |
|---|
| Gene | FBXO27 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 283 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (20)
Diseases linked to this target (Open Targets).
- body height · score 0.29
- lean body mass · score 0.29
- base metabolic rate measurement · score 0.23
- whole body water mass · score 0.22
- clear cell renal carcinoma · score 0.18
- fat body mass · score 0.17
- body weight · score 0.08
- hypertriglyceridemia 2 · score 0.05
- cholesterol-ester transfer protein deficiency · score 0.05
- Familial hemophagocytic lymphohistiocytosis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NI29-F1 | alphafold | PREDICTED | 91.23 | — |
Amino-acid sequence (283 residues)
MGASVSRGRA ARVPAPEPEP EEALDLSQLP PELLLVVLSH VPPRTLLGRC RQVCRGWRAL VDGQALWLLI LARDHGATGR ALLHLARSCQ SPARNARPCP LGRFCARRPI GRNLIRNPCG QEGLRKWMVQ HGGDGWVVEE NRTTVPGAPS QTCFVTSFSW CCKKQVLDLE EEGLWPELLD SGRIEICVSD WWGARHDSGC MYRLLVQLLD ANQTVLDKFS AVPDPIPQWN NNACLHVTHV FSNIKMGVRF VSFEHRGQDT QFWAGHYGAR VTNSSVIVRV RLS
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