About Ly6/PLAUR domain-containing protein 6B
Ly6/PLAUR domain-containing protein 6B (LYPD6B) is a protein
from Homo sapiens identified by UniProt accession
Q8NI32, 183 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | Ly6/PLAUR domain-containing protein 6B |
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| UniProt accession | Q8NI32 |
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| Gene | LYPD6B |
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| Organism | Homo sapiens |
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| Length | 183 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (40)
Diseases linked to this target (Open Targets).
- cortical surface area measurement · score 0.48
- neurodegenerative disease · score 0.45
- brain volume measurement · score 0.42
- neuroimaging measurement · score 0.42
- brain measurement · score 0.41
- cortical thickness · score 0.38
- PHF-tau measurement · score 0.31
- drug use measurement · score 0.13
- plasma fibronectin deficiency · score 0.06
- metabolite measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NI32-F1 | alphafold | PREDICTED | 80.09 | — |
Amino-acid sequence (183 residues)
MLYKSSDRPA HKVSMLLLCH ALAIAVVQIV IFSESWAFAK NINFYNVRPP LDPTPFPNSF KCFTCENAGD NYNCNRWAED KWCPQNTQYC LTVHHFTSHG RSTSITKKCA SRSECHFVGC HHSRDSEHTE CRSCCEGMIC NVELPTNHTN AVFAVMHAQR TSGSSAPTLY LPVLAWVFVL PLL
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