NF-kappa-B inhibitor delta (NFKBID)

About NF-kappa-B inhibitor delta

NF-kappa-B inhibitor delta (NFKBID) is a protein from Homo sapiens identified by UniProt accession Q8NI38, 313 residues long. MolForge cross-references it against 0 known binders and 158 disease associations.

Target properties

Protein name	NF-kappa-B inhibitor delta
UniProt accession	Q8NI38
Gene	NFKBID
Organism	Homo sapiens
Length	313 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (158)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.31
common variable immunodeficiency · score 0.16
infect · score 0.08
infection · score 0.08
combined immunodeficiency with skin granulomas · score 0.07
severe combined immunodeficiency due to CARD11 deficiency · score 0.07
isolated agammaglobulinemia · score 0.07
Hodgkins lymphoma · score 0.07
classic Hodgkin lymphoma · score 0.07
BENTA disease · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NI38-F1	alphafold	PREDICTED	87.83	—

Amino-acid sequence (313 residues)

MEAGPWRVSA PPSGPPQFPA VVPGPSLEVA RAHMLALGPQ QLLAQDEEGD TLLHLFAARG LRWAAYAAAE VLQVYRRLDI REHKGKTPLL VAAAANQPLI VEDLLNLGAE PNAADHQGRS VLHVAATYGL PGVLLAVLNS GVQVDLEARD FEGLTPLHTA ILALNVAMRP SDLCPRVLST QARDRLDCVH MLLQMGANHT SQEIKSNKTV LHLAVQAANP TLVQLLLELP RGDLRTFVNM KAHGNTALHM AAALPPGPAQ EAIVRHLLAA GADPTLRNLE NEQPVHLLRP GPGPEGLRQL LKRSRVAPPG LSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards