About Atypical kinase COQ8A, mitochondrial
Atypical kinase COQ8A, mitochondrial (COQ8A) is a protein
from Homo sapiens identified by UniProt accession
Q8NI60, 647 residues long.
MolForge cross-references it against 0 known binders and
205 disease associations.
Target properties
| Protein name | Atypical kinase COQ8A, mitochondrial |
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| UniProt accession | Q8NI60 |
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| Gene | COQ8A |
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| Organism | Homo sapiens |
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| Length | 647 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (205)
Diseases linked to this target (Open Targets).
- autosomal recessive ataxia due to ubiquinone deficiency · score 0.84
- coenzyme Q10 deficiency · score 0.75
- mean corpuscular volume · score 0.42
- neutrophil count · score 0.42
- genetic disorder · score 0.40
- lymphocyte percentage of leukocytes · score 0.38
- neutrophil percentage of leukocytes · score 0.38
- leukocyte count · score 0.37
- mitochondrial disease · score 0.36
- coenzyme Q10 deficiency, primary, 1 · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NI60-F1 | alphafold | PREDICTED | 69.64 | — |
Amino-acid sequence (647 residues)
MAAILGDTIM VAKGLVKLTQ AAVETHLQHL GIGGELIMAA RALQSTAVEQ IGMFLGKVQG QDKHEEYFAE NFGGPEGEFH FSVPHAAGAS TDFSSASAPD QSAPPSLGHA HSEGPAPAYV ASGPFREAGF PGQASSPLGR ANGRLFANPR DSFSAMGFQR RFFHQDQSPV GGLTAEDIEK ARQAKARPEN KQHKQTLSEH ARERKVPVTR IGRLANFGGL AVGLGFGALA EVAKKSLRSE DPSGKKAVLG SSPFLSEANA ERIVRTLCKV RGAALKLGQM LSIQDDAFIN PHLAKIFERV RQSADFMPLK QMMKTLNNDL GPNWRDKLEY FEERPFAAAS IGQVHLARMK GGREVAMKIQ YPGVAQSINS DVNNLMAVLN MSNMLPEGLF PEHLIDVLRR ELALECDYQR EAACARKFRD LLKGHPFFYV PEIVDELCSP HVLTTELVSG FPLDQAEGLS QEIRNEICYN ILVLCLRELF EFHFMQTDPN WSNFFYDPQQ HKVALLDFGA TREYDRSFTD LYIQIIRAAA DRDRETVRAK SIEMKFLTGY EVKVMEDAHL DAILILGEAF ASDEPFDFGT QSTTEKIHNL IPVMLRHRLV PPPEETYSLH RKMGGSFLIC SKLKARFPCK AMFEEAYSNY CKRQAQQ
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