About Proteasome subunit alpha-type 8
Proteasome subunit alpha-type 8 (PSMA8) is a protein
from Homo sapiens identified by UniProt accession
Q8TAA3, 256 residues long.
MolForge cross-references it against 0 known binders and
143 disease associations.
Target properties
| Protein name | Proteasome subunit alpha-type 8 |
|---|
| UniProt accession | Q8TAA3 |
|---|
| Gene | PSMA8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 256 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (143)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.46
- body height · score 0.37
- glioblastoma multiforme · score 0.37
- breast adenocarcinoma · score 0.30
- esophageal cancer · score 0.28
- squamous cell lung carcinoma · score 0.28
- head and neck squamous cell carcinoma · score 0.28
- gastric adenocarcinoma · score 0.27
- basophil count · score 0.24
- prostate adenocarcinoma · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TAA3-F1 | alphafold | PREDICTED | 83.73 | — |
Amino-acid sequence (256 residues)
MASRYDRAIT VFSPDGHLFQ VEYAQEAVKK GSTAVGIRGT NIVVLGVEKK SVAKLQDERT VRKICALDDH VCMAFAVLTI FIGLTADARV VINRARVECQ SHKLTVEDPV TVEYITRFIA TLKQKYTQSN GRRPFGISAL IVGFDDDGIS RLYQTDPSGT YHAWKANAIG RSAKTVREFL EKNYTEDAIA SDSEAIKLAI KALLEVVQSG GKNIELAIIR RNQPLKMFSA KEVELYVTEI EKEKEEAEKK KSKKSV
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