About GrpE protein homolog 2, mitochondrial
GrpE protein homolog 2, mitochondrial (GRPEL2) is a protein
from Homo sapiens identified by UniProt accession
Q8TAA5, 225 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | GrpE protein homolog 2, mitochondrial |
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| UniProt accession | Q8TAA5 |
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| Gene | GRPEL2 |
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| Organism | Homo sapiens |
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| Length | 225 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (25)
Diseases linked to this target (Open Targets).
- body height · score 0.23
- vital capacity · score 0.07
- neoplasm · score 0.05
- glioblastoma multiforme · score 0.04
- diabetes mellitus · score 0.04
- hepatocellular carcinoma · score 0.03
- esophageal squamous cell carcinoma · score 0.03
- forced expiratory volume · score 0.03
- mean platelet volume · score 0.02
- age-related hearing impairment · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TAA5-F1 | alphafold | PREDICTED | 78.64 | — |
Amino-acid sequence (225 residues)
MAVRSLWAGR LRVQRLLAWS AAWESKGWPL PFSTATQRTA GEDCRSEDPP DELGPPLAER ALRVKAVKLE KEVQDLTVRY QRAIADCENI RRRTQRCVED AKIFGIQSFC KDLVEVADIL EKTTECISEE SEPEDQKLTL EKVFRGLLLL EAKLKSVFAK HGLEKLTPIG DKYDPHEHEL ICHVPAGVGV QPGTVALVRQ DGYKLHGRTI RLARVEVAVE SQRRL
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