Vang-like protein 1 (VANGL1)

About Vang-like protein 1

Vang-like protein 1 (VANGL1) is a protein from Homo sapiens identified by UniProt accession Q8TAA9, 524 residues long. MolForge cross-references it against 0 known binders and 152 disease associations.

Target properties

Protein name	Vang-like protein 1
UniProt accession	Q8TAA9
Gene	VANGL1
Organism	Homo sapiens
Length	524 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (152)

Diseases linked to this target (Open Targets).

spina bifida · score 0.65
familial caudal dysgenesis · score 0.50
caudal regression sequence · score 0.40
optic disc size measurement · score 0.38
protein measurement · score 0.34
ferritin measurement · score 0.30
gut microbiome measurement · score 0.29
leukocyte count · score 0.26
neural tube defect · score 0.20
genetic disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TAA9-F1	alphafold	PREDICTED	75.60	—

Amino-acid sequence (524 residues)

MDTESTYSGY SYYSSHSKKS HRQGERTRER HKSPRNKDGR GSEKSVTIQP PTGEPLLGND STRTEEVQDD NWGETTTAIT GTSEHSISQE DIARISKDME DSVGLDCKRY LGLTVASFLG LLVFLTPIAF ILLPPILWRD ELEPCGTICE GLFISMAFKL LILLIGTWAL FFRKRRADMP RVFVFRALLL VLIFLFVVSY WLFYGVRILD SRDRNYQGIV QYAVSLVDAL LFIHYLAIVL LELRQLQPMF TLQVVRSTDG ESRFYSLGHL SIQRAALVVL ENYYKDFTIY NPNLLTASKF RAAKHMAGLK VYNVDGPSNN ATGQSRAMIA AAARRRDSSH NELYYEEAEH ERRVKKRKAR LVVAVEEAFI HIQRLQAEEQ QKAPGEVMDP REAAQAIFPS MARALQKYLR ITRQQNYHSM ESILQHLAFC ITNGMTPKAF LERYLSAGPT LQYDKDRWLS TQWRLVSDEA VTNGLRDGIV FVLKCLDFSL VVNVKKIPFI ILSEEFIDPK SHKFVLRLQS ETSV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards