About Josephin-2
Josephin-2 (JOSD2) is a protein
from Homo sapiens identified by UniProt accession
Q8TAC2, 188 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Josephin-2 |
|---|
| UniProt accession | Q8TAC2 |
|---|
| Gene | JOSD2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 188 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (26)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- glioblastoma multiforme · score 0.18
- non-small cell lung carcinoma · score 0.10
- hepatocellular carcinoma · score 0.08
- cholangiocarcinoma · score 0.08
- erythrocyte count · score 0.08
- neoplasm · score 0.07
- esophageal squamous cell carcinoma · score 0.07
- hemoglobin measurement · score 0.07
- hematocrit · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TAC2-F1 | alphafold | PREDICTED | 89.92 | — |
Amino-acid sequence (188 residues)
MSQAPGAQPS PPTVYHERQR LELCAVHALN NVLQQQLFSQ EAADEICKRL APDSRLNPHR SLLGTGNYDV NVIMAALQGL GLAAVWWDRR RPLSQLALPQ VLGLILNLPS PVSLGLLSLP LRRRHWVALR QVDGVYYNLD SKLRAPEALG DEDGVRAFLA AALAQGLCEV LLVVTKEVEE KGSWLRTD
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