About Proton-coupled zinc antiporter SLC30A5
Proton-coupled zinc antiporter SLC30A5 (SLC30A5) is a protein
from Homo sapiens identified by UniProt accession
Q8TAD4, 765 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Proton-coupled zinc antiporter SLC30A5 |
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| UniProt accession | Q8TAD4 |
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| Gene | SLC30A5 |
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| Organism | Homo sapiens |
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| Length | 765 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (68)
Diseases linked to this target (Open Targets).
- hydrops fetalis · score 0.33
- hypertrophic cardiomyopathy · score 0.33
- alkaline phosphatase measurement · score 0.29
- cardiomyopathy · score 0.23
- creatinine measurement · score 0.14
- vital capacity · score 0.14
- glomerular filtration rate · score 0.12
- systolic blood pressure · score 0.12
- protein measurement · score 0.12
- cystatin C measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TAD4-F1 | alphafold | PREDICTED | 76.22 | — |
Amino-acid sequence (765 residues)
MEEKYGGDVL AGPGGGGGLG PVDVPSARLT KYIVLLCFTK FLKAVGLFES YDLLKAVHIV QFIFILKLGT AFFMVLFQKP FSSGKTITKH QWIKIFKHAV AGCIISLLWF FGLTLCGPLR TLLLFEHSDI VVISLLSVLF TSSGGGPAKT RGAAFFIIAV ICLLLFDNDD LMAKMAEHPE GHHDSALTHM LYTAIAFLGV ADHKGGVLLL VLALCCKVGF HTASRKLSVD VGGAKRLQAL SHLVSVLLLC PWVIVLSVTT ESKVESWFSL IMPFATVIFF VMILDFYVDS ICSVKMEVSK CARYGSFPIF ISALLFGNFW THPITDQLRA MNKAAHQEST EHVLSGGVVV SAIFFILSAN ILSSPSKRGQ KGTLIGYSPE GTPLYNFMGD AFQHSSQSIP RFIKESLKQI LEESDSRQIF YFLCLNLLFT FVELFYGVLT NSLGLISDGF HMLFDCSALV MGLFAALMSR WKATRIFSYG YGRIEILSGF INGLFLIVIA FFVFMESVAR LIDPPELDTH MLTPVSVGGL IVNLIGICAF SHAHSHAHGA SQGSCHSSDH SHSHHMHGHS DHGHGHSHGS AGGGMNANMR GVFLHVLADT LGSIGVIVST VLIEQFGWFI ADPLCSLFIA ILIFLSVVPL IKDACQVLLL RLPPEYEKEL HIALEKIQKI EGLISYRDPH FWRHSASIVA GTIHIQVTSD VLEQRIVQQV TGILKDAGVN NLTIQVEKEA YFQHMSGLST GFHDVLAMTK QMESMKYCKD GTYIM
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