Smad nuclear-interacting protein 1 (SNIP1)

About Smad nuclear-interacting protein 1

Smad nuclear-interacting protein 1 (SNIP1) is a protein from Homo sapiens identified by UniProt accession Q8TAD8, 396 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.

Target properties

Protein name	Smad nuclear-interacting protein 1
UniProt accession	Q8TAD8
Gene	SNIP1
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (86)

Diseases linked to this target (Open Targets).

Christianson syndrome · score 0.63
neurodegenerative disease · score 0.52
Rolandic epilepsy · score 0.33
childhood epilepsy with centrotemporal spikes · score 0.33
intraocular pressure measurement · score 0.12
FEV/FVC ratio · score 0.09
forced expiratory volume · score 0.09
malignant epithelial tumor of ovary · score 0.09
cardiac hypertrophy · score 0.07
body mass index · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TAD8-F1	alphafold	PREDICTED	66.06	—

Amino-acid sequence (396 residues)

MKAVKSERER GSRRRHRDGD VVLPAGVVVK QERLSPEVAP PAHRRPDHSG GSPSPPTSEP ARSGHRGNRA RGVSRSPPKK KNKASGRRSK SPRSKRNRSP HHSTVKVKQE REDHPRRGRE DRQHREPSEQ EHRRARNSDR DRHRGHSHQR RTSNERPGSG QGQGRDRDTQ NLQAQEEERE FYNARRREHR QRNDVGGGGS ESQELVPRPG GNNKEKEVPA KEKPSFELSG ALLEDTNTFR GVVIKYSEPP EARIPKKRWR LYPFKNDEVL PVMYIHRQSA YLLGRHRRIA DIPIDHPSCS KQHAVFQYRL VEYTRADGTV GRRVKPYIID LGSGNGTFLN NKRIEPQRYY ELKEKDVLKF GFSSREYVLL HESSDTSEID RKDDEDEEEE EEVSDS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards