About WD repeat-containing protein 48
WD repeat-containing protein 48 (WDR48) is a protein
from Homo sapiens identified by UniProt accession
Q8TAF3, 677 residues long.
MolForge cross-references it against 0 known binders and
66 disease associations.
Target properties
| Protein name | WD repeat-containing protein 48 |
|---|
| UniProt accession | Q8TAF3 |
|---|
| Gene | WDR48 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 677 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (66)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- cancer · score 0.47
- autosomal recessive spastic paraplegia type 60 · score 0.37
- Spastic paraplegia · score 0.23
- breast adenocarcinoma · score 0.23
- platelet component distribution width · score 0.13
- hereditary spastic paraplegia · score 0.12
- hepatocellular carcinoma · score 0.08
- mitochondrial DNA measurement · score 0.07
- azoospermia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TAF3-F1 | alphafold | PREDICTED | 88.90 | — |
Amino-acid sequence (677 residues)
MAAHHRQNTA GRRKVQVSYV IRDEVEKYNR NGVNALQLDP ALNRLFTAGR DSIIRIWSVN QHKQDPYIAS MEHHTDWVND IVLCCNGKTL ISASSDTTVK VWNAHKGFCM STLRTHKDYV KALAYAKDKE LVASAGLDRQ IFLWDVNTLT ALTASNNTVT TSSLSGNKDS IYSLAMNQLG TIIVSGSTEK VLRVWDPRTC AKLMKLKGHT DNVKALLLNR DGTQCLSGSS DGTIRLWSLG QQRCIATYRV HDEGVWALQV NDAFTHVYSG GRDRKIYCTD LRNPDIRVLI CEEKAPVLKM ELDRSADPPP AIWVATTKST VNKWTLKGIH NFRASGDYDN DCTNPITPLC TQPDQVIKGG ASIIQCHILN DKRHILTKDT NNNVAYWDVL KACKVEDLGK VDFEDEIKKR FKMVYVPNWF SVDLKTGMLT ITLDESDCFA AWVSAKDAGF SSPDGSDPKL NLGGLLLQAL LEYWPRTHVN PMDEEENEVN HVNGEQENRV QKGNGYFQVP PHTPVIFGEA GGRTLFRLLC RDSGGETESM LLNETVPQWV IDITVDKNMP KFNKIPFYLQ PHASSGAKTL KKDRLSASDM LQVRKVMEHV YEKIINLDNE SQTTSSSNNE KPGEQEKEED IAVLAEEKIE LLCQDQVLDP NMDLRTVKHF IWKSGGDLTL HYRQKST
Explore WD repeat-containing protein 48 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets