Zinc finger protein 461 (ZNF461)

About Zinc finger protein 461

Zinc finger protein 461 (ZNF461) is a protein from Homo sapiens identified by UniProt accession Q8TAF7, 563 residues long. MolForge cross-references it against 0 known binders and 7 disease associations.

Target properties

Protein name	Zinc finger protein 461
UniProt accession	Q8TAF7
Gene	ZNF461
Organism	Homo sapiens
Length	563 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (7)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.03
platelet count · score 0.02
grip strength measurement · score 0.02
neoplasm · score 0.01
non-small cell lung carcinoma · score 0.01
Herpes simplex infection · score 0.00
Cerebral cortical atrophy · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TAF7-F1	alphafold	PREDICTED	65.26	—

Amino-acid sequence (563 residues)

MAHELVMFRD VAIDVSQEEW ECLNPAQRNL YKEVMLENYS NLVSLGLSVS KPAVISSLEQ GKEPWMVVRE ETGRWCPGTW KTWGFHNNFL DNNEATDINA DLASRDEPQK LSPKRDIYET ELSQWVNMEE FKSHSPERSI FSAIWEGNCH FEQHQGQEEG YFRQLMINHE NMPIFSQHTL LTQEFYDREK ISECKKCRKI FSYHLFFSHH KRTHSKELSE CKECTEIVNT PCLFKQQTIQ NGDKCNECKE CWKAFVHCSQ LKHLRIHNGE KRYECNECGK AFNYGSELTL HQRIHTGEKP YECKECGKAF RQRSQLTQHQ RLHTGEKPYE CKQCGKAFIR GFQLTEHLRL HTGEKPYECK ECGKTFRHRS HLTIHQRIHT GEKPYECREC GKAFSYHSSF SHHQKIHSGK KPYECHECGK AFCDGLQLTL HQRIHTGEKP YECKECGKTF RQCSHLKRHQ RIHTGEKPHE CMICGKAFRL HSHLIQHQRI HTGEKPYECK ECGKAFSYHS SFSHHQRIHS GKKPYQCGKA FNHRLQLNLH QTLHTGEKPV RFPLLPPHPS LAS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards